Testing Procedures

Types and dosages of drugsAlkylating agents , antimetabolites, plant alkaloids , topoisomerase inhibitors , antibiotics, anti-tumor : the majority of chemotherapy agents can be divided . And all these drugs affect to some extent on the synthesis and division , or function of DNA .Some newer agents do not act directly on the DNA . This is the case for tyrosine kinase inhibitor new imatinib mesylate, and directly target the molecular abnormalities in certain types of cancer ( cancer of the blood , and colon cancer ) .Other drugs affect the behavior of cancer cells without attacking the cells directly . Including hormones for this type of adjuvant therapy .Dose of chemotherapy can be very difficult : too low a dose to the tumor to be ineffective , while in excessive toxicity would be unbearable for the patient. Therefore it has been established in many hospitals " testing procedures " to get proper treatment.In general , and a dose of " body surface " of the patient, is set approximately by calculating the size and weight. Recently , scientists have small pumps on the surface of cancer cells to expel chemotherapy within the cell that have been identified . This research is a P -glycoprotein and other such waste micropumps active. Inhibitors - P -glycoprotein function has been run since June 2007 , and increase the effectiveness of chemotherapy

Brachytherapy

Chemotherapy because of the effect of the split , and the growth of tumors ( leukemia or Hodgkin's disease ) are more likely to treat , such as the vast majority of the cancer cells to make continuous cell division .Cancer cells are the result of several consecutive mutations of normal cells , which generally leads to the differentiation of other cells . Due to the special function in the body over time , and the cancer cells by mutations and gradually this differentiation and the normal operation of the collection lose . Chemicals used in chemotherapy more effective tumors affect " younger " (ie differences ) , there are usually kept in a cell at a higher level of differentiation at least the initial part of the process , and to control the spread. Also for the center of solid tumors , in particular, there is more cell division , which makes these cells resistant to chemotherapy . Another problem with solid tumors that are rarely used and the means of access to the center of the tumor. To resolve this issue , we use brachytherapy and surgery of course .

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Cancer chemotherapy

Another use of chemotherapeutic agents is the treatment of autoimmune diseases .Cancer chemotherapy ( anti- tumors )Cancer is the uncontrolled growth of cells ( cell degeneration ) by genetic mutations ( DNA damage ) and sometimes with hereditary and ready to develop some tumors.The majority of chemotherapy agents work by stopping the division ( cell division of the nucleus ) , which targets rapidly dividing cells . Because these substances can damage cells , so-called " toxic to the cells ." Some of these molecules leads to a real " cellular suicide " apoptosis .You can use most of the antineoplastic today , are not new drugs or a specific effect on the cancer cells so that they can also affect healthy cells . The progress can be seen in the context of a therapeutic drug administrations and the implementation of their collections.So far , the researchers are not able to certain characteristics of malignant cells that make recognizable to locate ( with the exception of a few recent examples such as " Philadelphia chromosome " of imatinib mesylate specifically ) . This means that other rapidly dividing cells , such as cells that are responsible for hair growth or renewal of the intestinal epithelium and blood cells are also affected . This explains the most common side effects such as hair loss , and inflammation ( the destruction of white blood cells ) , anemia ( destruction of red blood cells ) and bleeding ( the destruction of platelets ) . This sometimes requires a way to combat these side effects : in a sterile room , and blood transfusions , injections of erythropoietin (EPO), group , etc. .However, even the doctor to adjust some of the molecules with fewer side effects than other arrangements , and take advantage of them , in some patients , in some cases

Chemotherapy

Chemotherapy is the use of certain chemical substances to treat disease . It is Behandlungsverfahrenin itself as well as surgery. The first known use of chemotherapy in the use of Qena H. Indians in Peru , in the treatment of fevers such as malaria .

Discovered the father of modern chemotherapy Paul Ehrlich in his lab in 1908 arsphenamine Sahachiro Hatta , a compound of arsenic used to treat syphilis and trypanosomiasis . Later , came the development of sulfamidochrysoïdine Domagk , which allows pave the way for sulfamidothérapie1 laboratory Ernest Fourneau, and the discovery of penicillin by Alexander Fleming G in 1929 .

In common parlance , the term is used today , " chemotherapy " in the first instance to refer to the anti-cancer therapies . The rest of this article does not only deal with this particular issue . Referred to as antibiotic anti-bacterial , and chemotherapy , but in medical practice is a term usually used in connection with the treatment of tuberculosis .

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Mantadix

Mantadix drug blocks the receptors for other neurological also freed in the brains of patients with Parkinson's disease, and glutamate . It has the effect of an anti- Parkinson's modest , but it caused the distinction of being one of the few effective drugs dyskinesia by levodopa .Non-motor disorders medicineFludrocortisone or use Gutron a decrease in arterial blood pressure in some patients , even underestimate ( orthostatic hypotension ) , which reduces the risk of dizzy and fall that result.Exelon twice the memory and attention and declining mental abilities of the patients who suffer from mental impairment or dementia partially improved .Clozaril is the only treatment that hallucinations and improve the patients who suffer from any deterioration of motor disorders . But the drug requires close monitoring due to the biological potential toxicity of white blood cells .

Dopamine

Dopamine agonists work by mimicking the action of dopamine directly on the postsynaptic dopamine receptors with a moderate impact on the engine , and affects dopamine . Given the diversity of receptors , and there are also many varieties of clocks , each with special interest . It is usually as a first-line patients , especially if it has less than 65 to 70 years .. It produces less dyskinesia when levodopa before use . However, they lead to a higher degree than other side effects such as nausea dopamine latter , dizziness, and the risk of sleep attacks , hallucinations and behavioral disorders . You can also lead to swelling of the lower limbs . And should be monitored carefully rare side effects , is the emergence of various addictions ( gambling , shopping , sex , food ) . This effect , if it occurs , must be reported on the nerves .The most important names which are marketed in France cues Parlodel Dopergine, Trivastal, Requip and Sifrol ( stimuli second generation) (oral ) and Apokinon ( by the administration under the skin requires special pump or pen auto injector ) . Today , we prefer to use Trivastal, Requip or Sifrol because these drugs do not risk ( rare , but sometimes severe ) heart or lung fibrosis download the first generation agonist .Attention: News Lilly Laboratory Institute in April 20, 2011 judgment marketers agonsite Célance!Drugs inhibiting the degradation of dopamineThese inhibitors : they inhibit the action of certain enzymes originally levodopa motor complications .

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Levodopa

 Levodopa is associated with degeneration of nerve cells also induced motor complications term: efficiency fluctuations and involuntary movements ( dyskinesia ) . This causes motor complications is the fact that dopamine as a medicine is supplied to the progressive loss of dopamine in the brain of origin and other non- persistent in the brain , taken in the spring and according to this drug . ICOMT and inhibitors of MAO ( see below) : Levodopa may be combined with add-ons.May also cause large doses of levodopa , and other disorders such as hallucinations and lighting .Key names that will be marketed to levodopa in France : Modopar, Sinemet and Stalevo. Stalevo is slightly different from the first two in that it combines in one tablet of Sinemet and COMT inhibitor . Not shown this medication at the beginning of treatment, but the relay Modopar or Sinemet fluctuations occur when cars .