Saturday, September 8, 2012

Exacerbation Vs Corticosteroids


It was found that corticosteroids reduce the duration and severity of relapses and speed recovery, but not beyond a reasonable doubt that the increase of the overall rate of recovery, or that change the course of the disease in the long term.

ACTH (adrenocorticotropic hormone or ACTH) first drug to have proven effective in the recovery of acute exacerbations. Was administered intravenously methyl (IV) over short periods and at high doses (500 to 1000 mg MPIV / day for 3-5 days) ACTH largely because of its reliability, convenience suppress its image improve safety and perhaps put its consistent and faster. The extrapolation of the results of the study on the treatment of optic neuritis (inflammation of the optic nerve primary treatment) by neurologists many MS attacks in general.

In this study, 457 patients were randomly with optic neuritis to 1000 mg / day for 3 days on MPIV, then 1 mg / kg / day. Oral prednisone for 11 days, orally, 1 mg / kg / day of prednisone by mouth for 14 days or placebo feature study cases of inflammation of the optic nerve is the fact that also fits this requirement to assess the parameters sensitive (for example, the visual field, and contrast sensitivity, color vision and visual acuity).

Exacerbation


At least 80 to 85 Percent of people with MS during periods of exacerbation of their symptoms go at one time or another. This is a large, and sometimes worsen, and attacks or crises that bear by the sudden onset of a neurological disorder known for at least 24 hours in the absence of fever or infection. Outbreak of symptoms varies greatly. Layouts magnetic resonance imaging (MRI) taken during deceleration often show new active lesions in the brain (it increases in the presence of gadolinium) or old pest activate or expanded. Although most episodes of spontaneous, most medical professionals agree on the necessity of the treatment if they have important functional implications are.

Corticosteroids are the cornerstone for many years for the treatment of acute exacerbations. Because immune and anti-inflammatory effects, to restore the integrity of the blood-brain barrier to facilitate the return of myelin edema and improve nerve impulses

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Thursday, September 6, 2012

When Choosing a Particular Treatment


To consider when choosing a particular treatment (both medical and surgical, rehabilitation or replacement), it is very important that the scientific data on their effectiveness, risks and side effects. This is exactly the direction we set in the writing of this guide, our recommendations are based on peer-reviewed publications of scientific, whenever possible.

Assess the efficiency of treatment is the subject outside the scope of our mission is, in part because it is a parameter difficult to measure and varies depending on the type of management in health care in a particular place. However, we are an exception to this rule in Chapter 5, where we discuss alternative methods of treatment, both because they are not closely related to environmental health care is being run, because these processors are related, and non-medical and often a high price compared with the true benefits .

Completely new compared with previous editions, we have proposed guideline readings (in English) that the reader may consult, if they know more about the treatment, and how they were assessing their effectiveness and safety of the containment.

Studies in Alternative Treatments


Information is collected for studies in traditional and alternative treatments and. The Trials Register Cochrane controlled (Cochrane controlled trials register), which lists currently being evaluated, the results of randomized trials 4000 of alternative therapies, and more of an equal number of ongoing studies there are more than 200 reports of 0.40 treatments alternative assessment methodology in detail and you can find site (in English), and the Cochrane Library. Dr and Jeome, former editor of the Journal of Medical say that there will be two types of medicine, and traditional and alternative and: "There is only based medicine in the validated data, and other drugs, medicine, tangible results, which gives the results are uncertain .

"They complain that they have alternative means of treatment, but only so far, with the recognition that if the verification of scientific treatment, which proved its effectiveness and safety, it has no role in alternative medicine or traditional medicine" must, but replaced by assertions , speculation and the evidence is not scientific evidence. " They want "are equally alternative treatments for rigorous scientific evaluation of traditional remedies."

Mole Removal


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Some of them are iodine which helps in removing and reducing the mole, apple cider vinegar, a natural product, helps in reducing the size of the mole and the application of this product placed on the affected area after cleaning it either in the morning or evening can do wonders after a period of two to three weeks. . Vitamin C supplement crushed to form into a paste also helps tremendously when it is applied to the affected area and left to dry, with the desired results within s few weeks. Castor oil and baking powder, a mixed combination of paste also helps a great deal when applied to the affected area after thoroughly cleaning the skin and left to dry. The result can be seen after following this procedure for a week or so.

Tuesday, August 28, 2012

Clinical Trials


One can increase the value of statistical clinical study with a control group received a placebo, and the characteristics of this group should be as close as possible to those contained in the treated group (age, sex, and duration and the nature and severity of the disease, etc..) .. You can also disguise the nature of the treatment (drug or placebo) to the examiner, and the patient. This is known as a randomized, double-blind, placebo-controlled study. Determines the size and statistical power and the duration of study needed to get the correct results. Such clinical trials prove conclusively.

The results of the meta-analysis and more convincing. This type of study is to analyze the effectiveness and safety of treatment, based on the combined results of several clinical studies designed according to scientific protocol properly.

Monitoring Patients


To be meaningful, must provide evidence through monitoring the group of patients in the study of the available open the doctor and patient alike know that the drug administered.

Schedule a test, and treated and observed in the patients in the near future (prospective study) provide the strongest evidence that the ex-post evaluation of a group of patients in the past (retrospective test) treatment. Studies in the open, and there are a number of factors, the results seem in many cases cheaper than they make in reality. First, there will be biased in favor of improved references, and the results of treatment. Then there is the placebo effect: that the patient gets better, because he wants to heal, and that participation in clinical trials assured. Finally, there is a bias by excluding patients who stop treatment or who deteriorate and then the examiner the impression that the well-established that most of his patients, and data are received at the end of the day, especially on issues of response to treatment.

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Wednesday, August 22, 2012

Effectiveness of a Medicine


For the treatment of choice or therapeutic method to prevent and must be based on a symptom of the disease or on objective data to prove its safety and effectiveness are based.

However, there are several levels of evidence. Only to be confirmed by a neighbor on the effectiveness of a medicine (evidence) is very weak evidence. The same statement from a large number of people are certainly more weight, but is still far from conclusive evidence that a particular approach has its supporters, although its usefulness is questionable goal.

The fact that treatment will be used for many years, even centuries, is not conclusive evidence of their effectiveness. Just think of the bloodshed, which was practiced thousands of years ago, but we now know to be dangerous and even deadly, because it weakens the already sick patient. However, since a long time this practice is effective and was used widely since ancient times to the twentieth century.