Proteases

Macrophages secrete chemicals also called proteases (myelin destruction capable), prostaglandins, free radicals, and the immune system plays a role in inflammation and function. The second type of white blood cells are smaller cells. B-cells, including the maturity occurs in the bone marrow, we have a mission to produce antibodies. T cells, and a lot of maturity in reach of the thymus.

According to T-cell growth-and metabolism, and secrete cytokines material increases are activated once in response to exposure to the antigen. These activities and job promoting the growth of the population of lymphocytes, macrophages, and blood flow, leading to the formation of tissue edema and attract other types of white blood cells all over the infiltration. Interferon gamma is one of the cytokines secreted by activated T cells and facilitate the recognition of antigen. Associated with use in the treatment of MS with an increase in the frequency of relapses.

Differences Between

However, there are significant differences between the MS EAE and chronic. Contrary to what happens in EAE, it is difficult to detect antibodies against myelin proteins in the blood of patients suffering from Multiple Sclerosis. In FP, and we know that myelin antigen or one of its components, while in September, and we do not know yet. The antigen in question and in addition to that, to prevent and suppress EAE bit by a number of medicines that do not seem effective in September

The complex immune system. Its essential components are two types of white blood cells in the contract thymus, spleen and lymph found. These cells can circulate throughout the body through the bloodstream and lymphatic system. The largest of them is called macrophages ("macro" large Greek and "phage" eat) their job is to absorb and remove foreign objects.

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Experimental

There are nearly 60 years has been shown that injecting brain extracts from animals, in some cases cause an inflammatory disease of the central nervous system (CNS) and experimental allergic encephalitis (EAE). EAE is very similar to the human disease caused by the administration of the preparation containing fragments rabies vaccine ancient myelin. This form of encephalitis, in turn, is very similar to the pathology observed some forms of encephalomyelitis after infectious sometimes in children after a viral infection (measles, rubella, chicken pox, or otherwise). After infectious encephalomyelitis recurrent disease in humans.

Shortly thereafter, it was shown that it can cause chronic form of relapsing EAE in animals genetically engineered to have ready a few weeks or months and then after the initial recovery episode of paralysis, and the animals showed symptoms similar to those of the new MS. In addition, it was observed signs of harm in the central nervous system of these animals, similar to that of MS.

Better Understand The Disease

To better understand the disease better treatment

Although he does not know with certainty that the cause of MS is probably immune mediated process of environmental factors (perhaps viral infections) caused in genetically predisposed individuals. May be determined susceptibility for MS by multiple genes.

Current theories in favor of immune etiology of MS, it is not necessary little reminder theoretically. The immune system is to detect and destroy bacteria, viruses and other exotic materials (antigens). To do so, we must be able to distinguish any part of the anti-body, which is foreign to external influences. However, in certain medical conditions (autoimmune disease), the immune system no longer recognizes self components and MS attack, there is every reason to believe that the immune system attack the myelin occurs, a substance that form insulating sheath around the nerve fibers of many.

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Treatment, Main Issue

The main issue raised in this study, noted a small increase the size of the effect in each treatment group, and the probability of error of type 2 statistical (not identify the actual difference). It should in this context, it should be noted that the statistical methods are tools to detect the difference in the first place rather than similarity shows created can not be for lack of evidence of a difference to be considered as evidence of no difference.

It is extremely important not to extend corticosteroids, as is the custom that this treatment is associated with long-term complications. These complications include swelling spreads, the face of the moon, and psychosis, peptic ulcers, infections and acne. In the long term, can also cause treatment of serious side effects such as fractures, bone demineralization. Aseptic bone necrosis, and cataracts, high blood pressure and adrenal insufficiency

The Treatment of Patients

The treatment of patients suffering from PD consistently better than those who received placebo. After eight weeks of starting treatment, 32 p. The percent of patients in the placebo group developed an improvement of one point on a scale to assess disability (Expanded Disability within Center [EDSS]), while this number percent at 65. Percent in the group that received treatment with MP.

Another controlled study of recently in the UK, compared with MPIV MP by mouth. Patients were treated MS ninety within four weeks after the start of the outbreak. Of these patients, 38 MPIV (1000 mg / day for 3 days) and 42 MP oral (48 mg / day for 7 days, then 24 mg / day for 7 days and 12 mg / day for 7 days). Thus, the cumulative dose of methyl mg 3000 in Group D and 588 mg oral group. The primary endpoint was the difference between the two groups with regard to improving the EDSS (at least one point) after four weeks. Was measured no significant difference from pre-primary endpoint, or other parameters at one time or another during the study.

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Management Oral Steroids

Data on the effectiveness of oral steroids in the treatment of MS setbacks contradictory. In the study of optic neuritis mentioned above, in the months was observed after treatment, and increase the number of relapses in the group with oral prednisone placebo and treated by MPIV. However, among the experts to examine the results of this study, and there are many who reject the conclusion of the book is that oral prednisone for the subsequent increase in the frequency of relapses.

A recent study showed in Denmark effectiveness of methyl (MP) in the treatment of oral setbacks. Authors compared the effects of oral MP to placebo in patients who have suffered a series of less than 4 weeks. Received twenty-five patients and placebo and 26 500 mg / day given orally for 5 days MP, and cut from 10 days of treatment