Hypnosis

Certainly, this practice more than a century continues to feel some sulfur. "Such powers that resemble witchcraft or magic never existed in novels or films., But the mixture of strangeness and mystery horror allows to thicken and escape eyes that do not want to see, "François Roustang. This eminent specialist in February was the host of the Ling Foundation, Lausanne, through training for therapists.

Certainly, hypnosis contradicts our theoretical knowledge. This practice - the use of "stuff" but especially intuition and attention - is to arise in this hitherto unsuspected potentialities. This is the only magic, and this is already a lot. How is this possible? According to François Roustang, hypnosis induces wakefulness intense that allows us, in imagination, to anticipate and change our behaviors and actions. Therefore, it can become a way of life.

The human being is subject to two regimes of vigilance on the eve restricted own daily life, and ensures widespread, like deep sleep from which we dream, we bathed in our imagination. This duality appears not only when the hypnotic induction is performed.

Acupuncture

Issue, four centuries BC in China, and the Association of experimental philosophy, acupuncture is considering finally efficiency real and imaginary personal and especially valuable as a painkiller.

Acupuncture considered, like all Chinese medicine also, a concept often due to negligence is difficult to measure and impossible to understand intuitively: life energy. But without it ... Life does not!

The human body is through foreign channels, invisible but real, and that this energy flow: 14 main meridians. Walkable deep into the body and the surface, and thus unite the various internal organs and the skin surface. Their journey is full of surface points, acupuncture priceless. Each of these points is in fact a specific role, and can also be. The flow of energy along the meridian, either directly to the institution, but because every meridian passing through the area of the body, and connects to various devices, and to treat the surface of the skin sometimes prevented away from where energy. Stimulus is then passed one or the other of these points with a needle along the meridian energy flow again.

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Activity of the Disease,

Phase II studies (sample of 213 patients maximum) showed that relapse in MS, and monthly natalizumab injection given IV over a period of up to six months, and well-tolerated, and inhibits the activity of the disease, according to the (primary endpoint) MRI and reduces the frequency of relapses . Designed large Phase III trial to confirm the efficacy and safety of monthly management fourth natalizumab, either as a single therapy in combination with interferon beta.

Recent studies suggest that the beneficial effects of steroids and interferon beta in MS may be at least partly related to a reduction in the activity of certain MMPs and stimulating the production of tissue inhibitors MMPs. Also proved that MMP inhibitors effectively suppress EAE.

Can also manage future studies and nerve agents or molecules that renews axles, and the establishment of growth factors, and the proliferation and survival of oligodendrocytes (the cells that produce myelin) focus on stimulating the production of cell transplantation and myelin (for example, neural stem cells).

Blood Brain Barrier

Agents to reduce the damage to the blood-brain barrier
 
 The blood-brain barrier (BBB) is to protect the spinal cord and brain by preventing the cells and molecules of some of the inputs. In the early stages of MS, this barrier more permeable, and can not prevent the immune cells from the blood. Its way to the brain and the spinal cord was observed that the management of IFN beta, to reduce patients and animals with EAE in BBB permeability, thus preventing the formation of new lesions.

Is evaluating a number of novel compounds soon in MS studies, including antibodies against adhesion molecules, adhesion molecules soluble recombinant that compete with the binding of activated lymphocytes T-, as well as other anti-competitive adhesion molecules, such as selectins. Natalizumab (AntegrenMD) and he was the head of monoclonal antibodies against leukocyte integrin alpha4beta1 studied recently.

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Myelin basic protein and other peptides

 
 In the first phase study, we examined the effect of synthetic peptides intrathecal or intravenous myelin basic protein (MBP) concentrations of free and associated MBP-Semitism in the CSF. Been reported any significant side effects. Recent studies we to determine the safety and efficacy of peptide analogues of identifying MBP (modified peptide ligands). We believe that these peptides bind cell receptors T-, without causing the activation of these cells, but by stimulating the production of cytokines anti-inflammatory, instead of cytokines pro-inflammatory theoretically this could lead to disabling treatment strategy that selectively, and T cells play a role in the pathogenesis in MS.

Myelin Orally

 
 After the first pilot study on the induction of immune tolerance to myelin antigens, multicenter, randomized, conducted a double-blind, placebo-controlled study by oral administration of myelin. This study was conducted of the third stage in 14 centers in the United States and Canada. It included more than 500 patients with RRMS (EDSS scores of 4.5 or less), stratified by gender and phenotype DR2 (because we have observed in a previous study, men or HLA-DR2 without tend better to treatment). The primary endpoint was to study two-year relapse rate, while ultimately included secondary MRI. The results of this study showed no great benefit of oral myelin (MyloralMD) compared with placebo.

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Factors that stimulate specific immune

 
 Immunology is a strategy on the plane of complex events trimolecular to prevent activation of cells T-antigen specific when the expression of this disease by the antigen-presenting cells, cells T-, and displays the future of the interview, they lead to the production of proinflammatory myelin interaction lymphocytes. This can be achieved this strategy by the management of medicines (such as antibodies and monoclonal), which disrupts the party of receptor T cells by the administration of peptides that compete with antigen to bind to receptors can be achieved lymphocytes TT or vaccination cells with such interventions, Although it is theoretically very attractive, is not without its problems, and more importantly is the fact that we still can not find a specific immune response deviation in MS. The therapeutic ability of this strategy is highly skeptical, despite the fact that they are. Be very effective in EAE (an animal model of MS) even if it was possible to identify and target immune response mediated by type of lymphocytes are well characterized-T, this treatment is not possible because of the diversity of the immune response over time (and epitope phenomenon infection).