Showing posts with label tissue damage. Show all posts
Showing posts with label tissue damage. Show all posts
Thursday, October 11, 2012
Treatment with IVIG
Has large multicenter study in Europe and Canada for IVIG (1.0 g / kg / month) in secondary progressive MS. Results on the clinical and magnetic resonance imaging (MRI) is negative.
Treatment with IVIG rarely cause serious side effects. Including aseptic meningitis, kidney failure, and vascular injury and viral infections, eczema and anaphylaxis. Another potential problem associated with its use is high contrast composition of supplements on the market, confirmed by many studies.
Can exercise and in addition to the immunosuppressive effects (due to the fact that the suppression of the production of proinflammatory cytokines, or they contain antibodies to fight different styles self) promotion of IVIG leaning back, and according to some studies. However, small studies are performed at the Mayo Clinic does not support the hypothesis that IVIG can reverse neurological deficits and visual long.
Cytokines
Recent data show that cytokines can be divided into two categories. First. Of inflammatory cytokines, including tumor necrosis factor alpha (TNF alpha) and interferon gamma, which may direct tissue damage in MS second layer, and cytokines anti-inflammatory, including 4 - interleukin (IL-4), interleukin -10 (IL -10), and transforming growth factor beta (TGF-beta), to suppress or prevent the disease.
There are many B cells in MS plaques and close to the latter, but they are relatively rare in the cerebrospinal fluid (CSF). These are the cells to ensure local production of immune. Antibodies are immune, but in September, it's not nature made against this antigen antibodies. In an attempt to search, and students have to discover antigen antibody inconclusive so far.
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