Protocol Optimization

In addition, reduces treatment nearly half the pace of setbacks has no obvious effect on the severity of the outbreak. However, it is possible that not blind protocol optimization, which may be biased study results. Unfortunately, MRI are not included in the protocol, and the book did not produce any data on changes EDSS "confirmed" the three months and six months.

In another clinical study, we investigate the effect of high doses of IVIG (2.0 g / kg / month for 6 months) to assess disease activity as measured by magnetic resonance imaging (MRI), but there was a high dropout rate due to side effects.

In double-blind study, 40 patients Israeli with RRMS random IVIG because of loading dose (0.4 mg / kg / day for 5 days), followed by enhanced access to a unique (0.4 mg / kg) or placebo, administered every two months for two years. Treatment was reduced almost 40 percent. Percent in annual relapse rate, in addition to its impact on the EDSS. However, it did not differ significantly between the two groups in total lesion load on magnetic resonance imaging (MRI) of the brain.