Protocol Optimization

In addition, reduces treatment nearly half the pace of setbacks has no obvious effect on the severity of the outbreak. However, it is possible that not blind protocol optimization, which may be biased study results. Unfortunately, MRI are not included in the protocol, and the book did not produce any data on changes EDSS "confirmed" the three months and six months.

In another clinical study, we investigate the effect of high doses of IVIG (2.0 g / kg / month for 6 months) to assess disease activity as measured by magnetic resonance imaging (MRI), but there was a high dropout rate due to side effects.

In double-blind study, 40 patients Israeli with RRMS random IVIG because of loading dose (0.4 mg / kg / day for 5 days), followed by enhanced access to a unique (0.4 mg / kg) or placebo, administered every two months for two years. Treatment was reduced almost 40 percent. Percent in annual relapse rate, in addition to its impact on the EDSS. However, it did not differ significantly between the two groups in total lesion load on magnetic resonance imaging (MRI) of the brain.

Intravenous Immunoglobulin

Immunoglobulins (IgG) for intravenous administration (IVIG) have different effects on the immune system.

During the first small studies that did not show multicenter study wide effectiveness convincing Australian found that the monthly management of low-dose IVIG effective and well tolerated. A group of patients 148 RRMS (EDSS 1-6) randomly into two groups, one treated with IVIG monthly dose of 0.15 to 0.20 kg / g split and the other received a placebo for two years. Was ultimately the main effects of treatment on clinical disability (as measured by the change in EDSS), and the proportion of patients who have debilitating disability, remained stable or deteriorating (difference of one point at least on EDSS). The analysis is based on the plan showed that IVIG therapy have a significant positive impact, albeit modest, in EDSS.