Cytokines and Activity

Factors that interfere with the production of cytokines and Activity
 
 Especially in this context, was supposed to TNF-alpha may play a very important role: and it is expressed in MS lesions, and there seems to be a relationship between the production of TNF alpha and clinical disease activity may be. Moreover, it was shown that they have a number of side effects, such as stimulating the production of several proinflammatory cytokines production and other toxic effects on oligodendrocytes, cells that have the CNS myelin. On the other hand, showed TNF-alpha anti-inflammatory properties. TNF inhibitors specific biological development (for example, monoclonal anti-TNF, soluble TNF receptor constructs) were evaluated in preliminary studies on MS. In a pilot study, and processes rapidly progressive MS humanized anti-TNF monoclonal antibody administered by intravenous infusion. This treatment led to a transient increase in the number of active lesions on MRI, accompanied by a temporary increase in the number of immune cells and the concentration in the cerebrospinal fluid, which are connected to activate the immune system and increase the activity treatment of diseases. In a study in North America, the second phase, 168 patients were treated for most RRMS with fusion protein TNF soluble receptor (LenerceptMD). The number of patients who have a much higher setbacks in the group that received treatment than it was in the second group, which emphasizes the need to better clarify the role of TNF alpha in September

Monoclonal Antibodies to Lymphocytes

Monoclonal antibodies to lymphocytes (or against some subtypes of lymphocytes)
Antibodies are specific antibodies very, which can be directed against specific molecules selectively (for example, produced by the cells or molecules against only certain subgroups of lymphocytes). This makes them a tool to induce immune selective.

This treatment produced a deep drain lymphocytes, and warned of the overall appearance of new lesions on MRI. Interestingly, it was observed with a longer clinical deterioration of the situation in a large proportion of patients, despite the absence of new lesions, complex also induced hyperthyroidism in about one-third of patients.

In a Phase II study, we have monoclonal anti-CD4 fictional administration to reduce the number of CD4 +, but this intervention had no effect on the disease as measured by magnetic resonance imaging.

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