Thursday, November 29, 2012

Cytokines and Activity


Factors that interfere with the production of cytokines and Activity
 
 Especially in this context, was supposed to TNF-alpha may play a very important role: and it is expressed in MS lesions, and there seems to be a relationship between the production of TNF alpha and clinical disease activity may be. Moreover, it was shown that they have a number of side effects, such as stimulating the production of several proinflammatory cytokines production and other toxic effects on oligodendrocytes, cells that have the CNS myelin. On the other hand, showed TNF-alpha anti-inflammatory properties. TNF inhibitors specific biological development (for example, monoclonal anti-TNF, soluble TNF receptor constructs) were evaluated in preliminary studies on MS. In a pilot study, and processes rapidly progressive MS humanized anti-TNF monoclonal antibody administered by intravenous infusion. This treatment led to a transient increase in the number of active lesions on MRI, accompanied by a temporary increase in the number of immune cells and the concentration in the cerebrospinal fluid, which are connected to activate the immune system and increase the activity treatment of diseases. In a study in North America, the second phase, 168 patients were treated for most RRMS with fusion protein TNF soluble receptor (LenerceptMD). The number of patients who have a much higher setbacks in the group that received treatment than it was in the second group, which emphasizes the need to better clarify the role of TNF alpha in September

Monoclonal Antibodies to Lymphocytes


Monoclonal antibodies to lymphocytes (or against some subtypes of lymphocytes)
Antibodies are specific antibodies very, which can be directed against specific molecules selectively (for example, produced by the cells or molecules against only certain subgroups of lymphocytes). This makes them a tool to induce immune selective.

This treatment produced a deep drain lymphocytes, and warned of the overall appearance of new lesions on MRI. Interestingly, it was observed with a longer clinical deterioration of the situation in a large proportion of patients, despite the absence of new lesions, complex also induced hyperthyroidism in about one-third of patients.

In a Phase II study, we have monoclonal anti-CD4 fictional administration to reduce the number of CD4 +, but this intervention had no effect on the disease as measured by magnetic resonance imaging.

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Monday, November 19, 2012

Blood Marrow Development


The Committee believes that all therapeutic strategies listed in this section ("Salaries in development") will be the subject of further research before they can be determine their usefulness in MS. Currently, there can be used recommended outside clinical trials planning correctly.

While there are undoubtedly necessary tools to develop effective strategies for highly treatment of MS, it would be wise to give a lot of optimism was premature and approach new therapeutic based on the results of studies on a small scale, without the completion of the third phase of studies on more staff. This shows the situation through the latter case of roquinimex (LinomideMD), immunoprecipitation, promising results completed in two phases Studies II, but unfortunately at the time of the third phase of tests had to be taken, involving more than 1,500 patients, because we realized that he had a severe toxicity and cardiovascular. In the case of a disease such as MS, which is characterized by progressive deterioration of the deficit for many years, and serious side effects, even if they are rare, lasting impact on the development of new therapeutic.

Immune Response,


According to some empirical data, it appears that this type of deviation can lead in fact to increase the production of immune antibodies and thus to the deterioration of the disease.

Develop vehicles that run on initiation of the immune response, especially at this stage where the antigen is served for T cells of antigen-presenting cells, the latter through specific receptors. According to studies of EAE (an animal model of MS) and this strategy seems promising.

Development of materials that reflect the blood-brain barrier to achieve stability in to restrict access to the central nervous system stimulant of immune cells. The relationship of this mechanism of magnetic resonance studies of IFN beta, which means that the effectiveness of the latter evidenced in part the impact of such on the blood-brain barrier, and demonstrated performance.

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Treatments in Development


  As mentioned above, refers to a growing body of evidence that the cause of MS is the result of a defect in the immune system, which lymphocytes, macrophages and cytokines play a pivotal role. Therefore, we have developed different strategies for therapeutic intervention on different parameters of the immune and inflammatory responses, or block. These strategies rely different orientations.

The development of drugs that stimulate the immune more selective to avoid potential side effects associated with generalized immune.

Development of materials. On cytokine production by promoting anti-inflammatory cytokines (IL-4, IL-5 and IL-10) at the expense of cytokine production pro-inflammatory (IL-2, IFN-gamma, alpha tumor necrosis factor) data indicate that IFN-beta clinical signs in reducing This much activity on MRI, along with a note that this will be the impact of a change in the balance between pro-inflammatory cytokines and anti-inflammatory cytokines is an important criterion for research in this area have lead.

Hematopoietic


Bone marrow or stem cells of Hematopoietic
 
 I will use bone marrow transplantation (BMT), widely in the treatment of various forms of cancer, and more recently, and the results of some studies that appeared it might be useful in the treatment of autoimmune diseases. They are strong immunosuppressive treatment with high-dose chemotherapy or total body radiation through (IV infusion) stem cells of hematopoietic bone marrow transplants. In the first months after transplantation BMT patients at high risk for complications, some fatal. This intervention was effective in EAE, and there is anecdotal evidence (well documented) effective September call A European study on bone marrow transplants and blood is currently developing guidelines specify criteria for selecting patients and transplant operations for future studies.

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Saturday, November 3, 2012

Medical Traditions of Ancient Greece


By its nature and founded securely connected physiotherapy medical traditions of ancient Greece. Principles governing the exercise of our day to naturopathic Heavily much for the "Hippocratic Corpus", and 20, the basis of Western medicine, the fifth century BC to the early century formed. Here are the main lines.

nocere is primum no - first do no harm. Can the symptoms of the disease (fever, for example) to be signs of a healing process. Therefore may harm their simple delete than good. Interventions need to enhance the natural healing process, not a prescription.

Screw medicatix naturae - nature and its own healing power. Body has an innate ability to restore and maintain health, if lost. In the heart of the neighborhood, the forces of life to achieve this. The role of the doctor or therapist. Access to these forces that make it easier to detect and remove barriers

large causam - detection and treatment of the cause. Doctors should be tried causes of the disease, rather than trying to suppress the symptoms. The disease is seen as the final result of a particular disease. You can restore the natural balance that carried out work on the causes of the disease.

Docere - teaching. The patient's doctor should be directed on the road to recovery and maintain their health naturally. Him to teach him to take care of themselves and make their own healing process and in accordance with the following principles:

* And a holistic approach. Says the processor of the patient working for his illness as a result of a complex interaction of mental, physical and emotional, spiritual, and should be on every one of them.

* Food. It teaches you how to eat so as to obtain all the nutrients essential for health, to avoid the use of synthetic drugs or surgery.

* Prevention (CDC). Finally taught him how to behave to maximize environmental and lifestyle, strength and well-being, and ultimately the risk of disease.

Naturopathy or Naturopathic


In countries where there are no strict rules for physical therapy - as is the case for several Francophone countries - to use the medicine is a natural and physical therapy are used interchangeably. In English, there is an obstacle, physical therapy, and in the countries in which they have been officially recognized discipline, and there is a doctor in physical therapy (ND), and not in natural medicine. On the other side of the origin of the word is Naturopathy is uncertain. Probably comes from the Latin: NATURO, nature and Greek: Patty, suffering. Means physical therapy, suffer - or disease - from nature. But perhaps more German word: path resulting path. Physical therapy is the path (Health) of nature.

Physiotherapy is a complete medical system, and the ongoing efforts in the first place mechanisms to stimulate the body's natural healing. Naturopathic interventions to activate the first place to promote and strengthen the mechanisms to eliminate these symptoms or instead of attacking pathogens directly. You will also need a soft and non-invasive as possible.

Among the most important tools for natural medicine, we find, among other things, herbal medicine, nutrition, homeopathy, aromatherapy, and physical manipulation, and so on stress management techniques.

For a better understanding of what today's physical therapy, it may be logical to its origins dating back to 2500, and remember its recent development, for a hundred years.
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