Harmful Germs

People often forget the other elements in fruits and vegetables. People often do not recognize the other and affect tomatoes, oranges, lemons and other fruits and vegetables in the store. Even if eaten the bark, can easily transfer bacteria into the fruit with a knife when they make their way through an orange. Wash fruit before cutting the risk of the spread of germs and greatly reduced.

Colds and flu viruses are not the only seeds that wander on surfaces. There are other harmful germs. MRSA (methicillin-resistant Staphylococcus aureus) are those that captured the attention of the press in recent years. At this time of the population over and international travel, and the spread of germs faster than ever. If you can follow these simple steps to reduce the chance of contact with the disease and stay healthier.

Risk of bacterial or viral infection

Ways to reduce the risk of bacterial or viral infection

When traveling on a plane when someone close to you cough or sneeze, to be put to Dr.  this week to propose to wear a mask. If possible, try to go to the sites in the plane, if the person refuses. Survey folding tables, and buttons with a disinfectant cloth arm.

Wear a pair of socks or socks at the airport. If shoes to go through security, and put socks. Transfer germs on the floor with your feet. Many airports now offer socks for travelers.

Stay away from the crowds, and this is another way to reduce the risk of bacterial or viral infection. Many people these days are handshake to avoid. If this is unavoidable should, or wash your hands washed with disinfectant gel as soon as possible.

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Jogging - Great Exercise

Extensor:About 10% of the contestants. This is when the outer space is more. And starts on the outside of the heel, and then along the outer edge of the foot to return to the finals inside points. Wear outsole structure and therefore on the outer side.

Depression:And depression accounts for 40% of the population. That is, if the site is more than the inner side of the foot. The movement begins abroad proceed quickly on the inside of the foot, and this is the front part of the foot under the big toe.

Depression
Will say that this is the kind of foot "naturally" without defect. They represent about 50% of the population. Wearing heels is a regular on each side. Communication is at the outer edge of the heel support performed over the entire foot and are prepared pressure big toe.

Jogging

Before discussing the various steps, and remember that incredible mechanical foot 26 bones, 16 joints, 107 ligaments and muscles 20, not less. With each step, your foot, for example, supports a large athletic 75kg press through every keystroke to pay 300kg when he was working at a steady pace.The first thing you should do if you feel discomfort when walking, is to look at the side of the foot. Private and wear shoes that you wear during your jogging sessions. I ask you your business. On the table and they look back If your shoes directly without turning, you are global, so you. Not have balance problems if the collapse to the inside, and that race in the Cup. Finally, in contrast to the extensor, when slack abroad.

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Professional Cleaning

Orthodontics is a dentist who has made specialty, it takes for the correct positioning of the teeth. It is advisable to go see soon enough, especially if the child sucks his thumb, and one or more fingers, as this may affect the position of the teeth.

Dentist for children is a dentist who voted, and devoted exclusively to children.

Dentist or dental dental care. In the hospital, and the dentist working in dental service.

Dentistry is the drug in the mouth and teeth. Dentist (or oral) is a doctor who has specialized in oral and dental surgery. Education is more than just a dentist.

Vaccination: How does it work ?

Vaccination is a way. One person against the development of certain infectious diseases, protection from microbes (bacteria or viruses) before they are affected by these diseases

If vaccination in the body to kill bacteria or weakened or become inactive venom is injected (toxoid).

Microbe, render harmless, do not cause disease. On the other hand, recognize the body as if it were an active and produces antibodies to eliminate them.

The immune system and keep the memory of this antibody. Therefore, when the microbe exists, the body produces antibodies more quickly to prevent especially against these microbes and disease incidence.

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Hypnosis

Certainly, this practice more than a century continues to feel some sulfur. "Such powers that resemble witchcraft or magic never existed in novels or films., But the mixture of strangeness and mystery horror allows to thicken and escape eyes that do not want to see, "François Roustang. This eminent specialist in February was the host of the Ling Foundation, Lausanne, through training for therapists.

Certainly, hypnosis contradicts our theoretical knowledge. This practice - the use of "stuff" but especially intuition and attention - is to arise in this hitherto unsuspected potentialities. This is the only magic, and this is already a lot. How is this possible? According to François Roustang, hypnosis induces wakefulness intense that allows us, in imagination, to anticipate and change our behaviors and actions. Therefore, it can become a way of life.

The human being is subject to two regimes of vigilance on the eve restricted own daily life, and ensures widespread, like deep sleep from which we dream, we bathed in our imagination. This duality appears not only when the hypnotic induction is performed.

Acupuncture

Issue, four centuries BC in China, and the Association of experimental philosophy, acupuncture is considering finally efficiency real and imaginary personal and especially valuable as a painkiller.

Acupuncture considered, like all Chinese medicine also, a concept often due to negligence is difficult to measure and impossible to understand intuitively: life energy. But without it ... Life does not!

The human body is through foreign channels, invisible but real, and that this energy flow: 14 main meridians. Walkable deep into the body and the surface, and thus unite the various internal organs and the skin surface. Their journey is full of surface points, acupuncture priceless. Each of these points is in fact a specific role, and can also be. The flow of energy along the meridian, either directly to the institution, but because every meridian passing through the area of the body, and connects to various devices, and to treat the surface of the skin sometimes prevented away from where energy. Stimulus is then passed one or the other of these points with a needle along the meridian energy flow again.

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Activity of the Disease,

Phase II studies (sample of 213 patients maximum) showed that relapse in MS, and monthly natalizumab injection given IV over a period of up to six months, and well-tolerated, and inhibits the activity of the disease, according to the (primary endpoint) MRI and reduces the frequency of relapses . Designed large Phase III trial to confirm the efficacy and safety of monthly management fourth natalizumab, either as a single therapy in combination with interferon beta.

Recent studies suggest that the beneficial effects of steroids and interferon beta in MS may be at least partly related to a reduction in the activity of certain MMPs and stimulating the production of tissue inhibitors MMPs. Also proved that MMP inhibitors effectively suppress EAE.

Can also manage future studies and nerve agents or molecules that renews axles, and the establishment of growth factors, and the proliferation and survival of oligodendrocytes (the cells that produce myelin) focus on stimulating the production of cell transplantation and myelin (for example, neural stem cells).

Blood Brain Barrier

Agents to reduce the damage to the blood-brain barrier
 
 The blood-brain barrier (BBB) is to protect the spinal cord and brain by preventing the cells and molecules of some of the inputs. In the early stages of MS, this barrier more permeable, and can not prevent the immune cells from the blood. Its way to the brain and the spinal cord was observed that the management of IFN beta, to reduce patients and animals with EAE in BBB permeability, thus preventing the formation of new lesions.

Is evaluating a number of novel compounds soon in MS studies, including antibodies against adhesion molecules, adhesion molecules soluble recombinant that compete with the binding of activated lymphocytes T-, as well as other anti-competitive adhesion molecules, such as selectins. Natalizumab (AntegrenMD) and he was the head of monoclonal antibodies against leukocyte integrin alpha4beta1 studied recently.

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Myelin basic protein and other peptides

 
 In the first phase study, we examined the effect of synthetic peptides intrathecal or intravenous myelin basic protein (MBP) concentrations of free and associated MBP-Semitism in the CSF. Been reported any significant side effects. Recent studies we to determine the safety and efficacy of peptide analogues of identifying MBP (modified peptide ligands). We believe that these peptides bind cell receptors T-, without causing the activation of these cells, but by stimulating the production of cytokines anti-inflammatory, instead of cytokines pro-inflammatory theoretically this could lead to disabling treatment strategy that selectively, and T cells play a role in the pathogenesis in MS.

Myelin Orally

 
 After the first pilot study on the induction of immune tolerance to myelin antigens, multicenter, randomized, conducted a double-blind, placebo-controlled study by oral administration of myelin. This study was conducted of the third stage in 14 centers in the United States and Canada. It included more than 500 patients with RRMS (EDSS scores of 4.5 or less), stratified by gender and phenotype DR2 (because we have observed in a previous study, men or HLA-DR2 without tend better to treatment). The primary endpoint was to study two-year relapse rate, while ultimately included secondary MRI. The results of this study showed no great benefit of oral myelin (MyloralMD) compared with placebo.

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Factors that stimulate specific immune

 
 Immunology is a strategy on the plane of complex events trimolecular to prevent activation of cells T-antigen specific when the expression of this disease by the antigen-presenting cells, cells T-, and displays the future of the interview, they lead to the production of proinflammatory myelin interaction lymphocytes. This can be achieved this strategy by the management of medicines (such as antibodies and monoclonal), which disrupts the party of receptor T cells by the administration of peptides that compete with antigen to bind to receptors can be achieved lymphocytes TT or vaccination cells with such interventions, Although it is theoretically very attractive, is not without its problems, and more importantly is the fact that we still can not find a specific immune response deviation in MS. The therapeutic ability of this strategy is highly skeptical, despite the fact that they are. Be very effective in EAE (an animal model of MS) even if it was possible to identify and target immune response mediated by type of lymphocytes are well characterized-T, this treatment is not possible because of the diversity of the immune response over time (and epitope phenomenon infection).

Other cytokines

 The first and second phase in progress to the therapeutic potential of TGF beta and IL-10, and two anti-inflammatory cytokines, and to consider at the moment for recombinant products. Since associated with the production of IL-12 with the progress of the disease and that may prevent by management that EAE anti-12-IL, these antibodies, in a clinical study evaluating the treatment of MS. Currently, it is still premature to take a decision on the therapeutic ability. You should know that many cytokines, and different functions, depending on the context, and more importantly, in the first place to work locally on the likely unintended consequences when administered into the general circulation.

Pentoxifylline is a phosphodiesterase inhibitor, which promotes the production of anti-inflammatory cytokines and prevent pro-inflammatory cytokines, while reducing the production of TNF-alpha. It has been shown to be effective in suppressing EAE. Are examined therapeutic ability in MS in a series of experimental studies. Its effects on various parameters of the immune system (CSF all of the blood) as well as magnetic resonance imaging and clinical, however, has been disappointing so far. According to a study, it was used for side effects., Associated with the early stages of antiretroviral therapy with interferon beta

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Cytokines and Activity

Factors that interfere with the production of cytokines and Activity
 
 Especially in this context, was supposed to TNF-alpha may play a very important role: and it is expressed in MS lesions, and there seems to be a relationship between the production of TNF alpha and clinical disease activity may be. Moreover, it was shown that they have a number of side effects, such as stimulating the production of several proinflammatory cytokines production and other toxic effects on oligodendrocytes, cells that have the CNS myelin. On the other hand, showed TNF-alpha anti-inflammatory properties. TNF inhibitors specific biological development (for example, monoclonal anti-TNF, soluble TNF receptor constructs) were evaluated in preliminary studies on MS. In a pilot study, and processes rapidly progressive MS humanized anti-TNF monoclonal antibody administered by intravenous infusion. This treatment led to a transient increase in the number of active lesions on MRI, accompanied by a temporary increase in the number of immune cells and the concentration in the cerebrospinal fluid, which are connected to activate the immune system and increase the activity treatment of diseases. In a study in North America, the second phase, 168 patients were treated for most RRMS with fusion protein TNF soluble receptor (LenerceptMD). The number of patients who have a much higher setbacks in the group that received treatment than it was in the second group, which emphasizes the need to better clarify the role of TNF alpha in September

Monoclonal Antibodies to Lymphocytes

Monoclonal antibodies to lymphocytes (or against some subtypes of lymphocytes)
Antibodies are specific antibodies very, which can be directed against specific molecules selectively (for example, produced by the cells or molecules against only certain subgroups of lymphocytes). This makes them a tool to induce immune selective.

This treatment produced a deep drain lymphocytes, and warned of the overall appearance of new lesions on MRI. Interestingly, it was observed with a longer clinical deterioration of the situation in a large proportion of patients, despite the absence of new lesions, complex also induced hyperthyroidism in about one-third of patients.

In a Phase II study, we have monoclonal anti-CD4 fictional administration to reduce the number of CD4 +, but this intervention had no effect on the disease as measured by magnetic resonance imaging.

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Blood Marrow Development

The Committee believes that all therapeutic strategies listed in this section ("Salaries in development") will be the subject of further research before they can be determine their usefulness in MS. Currently, there can be used recommended outside clinical trials planning correctly.

While there are undoubtedly necessary tools to develop effective strategies for highly treatment of MS, it would be wise to give a lot of optimism was premature and approach new therapeutic based on the results of studies on a small scale, without the completion of the third phase of studies on more staff. This shows the situation through the latter case of roquinimex (LinomideMD), immunoprecipitation, promising results completed in two phases Studies II, but unfortunately at the time of the third phase of tests had to be taken, involving more than 1,500 patients, because we realized that he had a severe toxicity and cardiovascular. In the case of a disease such as MS, which is characterized by progressive deterioration of the deficit for many years, and serious side effects, even if they are rare, lasting impact on the development of new therapeutic.

Immune Response,

According to some empirical data, it appears that this type of deviation can lead in fact to increase the production of immune antibodies and thus to the deterioration of the disease.

Develop vehicles that run on initiation of the immune response, especially at this stage where the antigen is served for T cells of antigen-presenting cells, the latter through specific receptors. According to studies of EAE (an animal model of MS) and this strategy seems promising.

Development of materials that reflect the blood-brain barrier to achieve stability in to restrict access to the central nervous system stimulant of immune cells. The relationship of this mechanism of magnetic resonance studies of IFN beta, which means that the effectiveness of the latter evidenced in part the impact of such on the blood-brain barrier, and demonstrated performance.

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Treatments in Development

  As mentioned above, refers to a growing body of evidence that the cause of MS is the result of a defect in the immune system, which lymphocytes, macrophages and cytokines play a pivotal role. Therefore, we have developed different strategies for therapeutic intervention on different parameters of the immune and inflammatory responses, or block. These strategies rely different orientations.

The development of drugs that stimulate the immune more selective to avoid potential side effects associated with generalized immune.

Development of materials. On cytokine production by promoting anti-inflammatory cytokines (IL-4, IL-5 and IL-10) at the expense of cytokine production pro-inflammatory (IL-2, IFN-gamma, alpha tumor necrosis factor) data indicate that IFN-beta clinical signs in reducing This much activity on MRI, along with a note that this will be the impact of a change in the balance between pro-inflammatory cytokines and anti-inflammatory cytokines is an important criterion for research in this area have lead.

Hematopoietic

Bone marrow or stem cells of Hematopoietic
 
 I will use bone marrow transplantation (BMT), widely in the treatment of various forms of cancer, and more recently, and the results of some studies that appeared it might be useful in the treatment of autoimmune diseases. They are strong immunosuppressive treatment with high-dose chemotherapy or total body radiation through (IV infusion) stem cells of hematopoietic bone marrow transplants. In the first months after transplantation BMT patients at high risk for complications, some fatal. This intervention was effective in EAE, and there is anecdotal evidence (well documented) effective September call A European study on bone marrow transplants and blood is currently developing guidelines specify criteria for selecting patients and transplant operations for future studies.

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Medical Traditions of Ancient Greece

By its nature and founded securely connected physiotherapy medical traditions of ancient Greece. Principles governing the exercise of our day to naturopathic Heavily much for the "Hippocratic Corpus", and 20, the basis of Western medicine, the fifth century BC to the early century formed. Here are the main lines.

nocere is primum no - first do no harm. Can the symptoms of the disease (fever, for example) to be signs of a healing process. Therefore may harm their simple delete than good. Interventions need to enhance the natural healing process, not a prescription.

Screw medicatix naturae - nature and its own healing power. Body has an innate ability to restore and maintain health, if lost. In the heart of the neighborhood, the forces of life to achieve this. The role of the doctor or therapist. Access to these forces that make it easier to detect and remove barriers

large causam - detection and treatment of the cause. Doctors should be tried causes of the disease, rather than trying to suppress the symptoms. The disease is seen as the final result of a particular disease. You can restore the natural balance that carried out work on the causes of the disease.

Docere - teaching. The patient's doctor should be directed on the road to recovery and maintain their health naturally. Him to teach him to take care of themselves and make their own healing process and in accordance with the following principles:

* And a holistic approach. Says the processor of the patient working for his illness as a result of a complex interaction of mental, physical and emotional, spiritual, and should be on every one of them.

* Food. It teaches you how to eat so as to obtain all the nutrients essential for health, to avoid the use of synthetic drugs or surgery.

* Prevention (CDC). Finally taught him how to behave to maximize environmental and lifestyle, strength and well-being, and ultimately the risk of disease.

Naturopathy or Naturopathic

In countries where there are no strict rules for physical therapy - as is the case for several Francophone countries - to use the medicine is a natural and physical therapy are used interchangeably. In English, there is an obstacle, physical therapy, and in the countries in which they have been officially recognized discipline, and there is a doctor in physical therapy (ND), and not in natural medicine. On the other side of the origin of the word is Naturopathy is uncertain. Probably comes from the Latin: NATURO, nature and Greek: Patty, suffering. Means physical therapy, suffer - or disease - from nature. But perhaps more German word: path resulting path. Physical therapy is the path (Health) of nature.

Physiotherapy is a complete medical system, and the ongoing efforts in the first place mechanisms to stimulate the body's natural healing. Naturopathic interventions to activate the first place to promote and strengthen the mechanisms to eliminate these symptoms or instead of attacking pathogens directly. You will also need a soft and non-invasive as possible.

Among the most important tools for natural medicine, we find, among other things, herbal medicine, nutrition, homeopathy, aromatherapy, and physical manipulation, and so on stress management techniques.

For a better understanding of what today's physical therapy, it may be logical to its origins dating back to 2500, and remember its recent development, for a hundred years.
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Acyclovir ZoviraxMD

Acyclovir (ZoviraxMD) antiviral and other Could be a viral infection to play an etiologic role in the pathogenesis of MS. This assumption was the basis used to achieve a double-blind, drugs, and random acyclovir in the treatment of herpes infections. Patients who received sixty RRMS acyclovir (800 mg) or placebo administered three times per day. Treatment was associated with activity has been reduced 34 percent. Percent in annual relapse rate, which confirms the value of further research and related vehicles acyclovir. In a recent study of magnetic resonance imaging (MRI) data on disease activity and showed no obvious effect valaciclovir, although positive results can not be denied in the subsets of September rights

Cortical, Plasma

Produced treatment for long periods of time with corticosteroids any positive effect on the development of disability and frequency of relapses. Moreover, it can cause serious side effects including osteoporosis aseptic bone necrosis, proximal muscle weakness and high blood pressure, high blood sugar and cataracts, and mental disorders. Said recently that intravenous corticosteroids monthly may slow the progression of disability and associated interferon beta-1b, corticosteroids can reduce the production of antibodies.

A Canadian study in a large, multi-center, placebo-controlled, for a period of two years, we have shown. Value in the treatment of plasma MS were obtained deficit reduction to present themselves with a combination therapy with plasma and oral prednisone and cyclophosphamide with placebo and plasma Sham.

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Interferon Alpha

How IFN beta, alpha IFN type of IFN 1 (see the section on beta IFN). Because both of the same receptors Substances Act, it is reasonable to IFN alpha has a positive effect on the development of MS. The first large-scale clinical trials of recombinant interferon alpha, based on 98 patients for a year in the randomized double-blind protocol, has shown placebo-controlled followed, focused, great benefits.

A study recently conducted in Italy, where 20 patients MRI within six months. Found that new or improved pest were more frequent in the second set, and the frequency of relapses. This study of alpha IFN doses higher than previous studies in the management of every two days focused by intramuscular injection.

Sulfasalazine

sulfasalazine and is a safe, well-established, and endowed with well-known anti-inflammatory and immune that was used for decades in the treatment of inflammatory diseases of the intestine. Was later discovered to have a positive effect on rheumatoid arthritis. Recently, we published the results of a collaborative study of the third stage, double-blind, placebo-controlled study from the Mayo Clinic, Canada's sulfasalazine in the treatment of Active MS. 99 patients were treated in the emergency percent with active MS with sulfasalazine (up to 2 g / day) or placebo, and observed for at least three years (mean follow-up 3.7 years). Although the short-term response has (2 years) preferential treatment can prevent or slow the progression of disability by the primary endpoint measure appeared (confirmed worsening EDSS one point at least for a period of consecutive examinations at intervals of 3 months).

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Home Toxic Effects

In a recently published the results of a multicenter European Phase II trial, which placebo-controlled, randomized, blind protocol.Found a significant positive impact on the frequency of relapses and the evolution of the deficit, and not accompanied by acute toxic effects. The information MRI beneficial effect on disease activity. Treatment was well tolerated. Although the results of this study led to the approval of mitoxantrone for the treatment of MS by the FDA in 2002, was not published the results in a scientific journal with peer review.

Home toxic effects of mitoxantrone is myelosuppression and cardiotoxicity dose.

Therefore, if the treatment with mitoxantrone, it is extremely important that patients who suffer from heart disease and an observer (depending on the treatment regimen used) ECG, blood and urine analysis to exclude the results on a monthly basis and an echocardiogram every six months.

Mitoxantrone

 Mitoxantrone is mediated antineoplastic agent with a strong immunological effects, including by inhibiting immune B cells and lymphocytes-T, is much less toxic anti-cancer drugs other, is the most common serious side effects cardiotoxicity. This compound is the subject of three trials for the treatment of MS in recent years.

Last placebo-controlled, randomized, conducted in Italy of 51 patients with RRMS. The treatment was to be in the 8 mg/m2 administered intravenously once a month for a year. A were measured downward trend in disease activity by evaluating clinical outcomes and magnetic resonance imaging (MRI) and shown in this study.

Conducted last placebo-controlled, randomized, with the expected duration of two years in Italy, from 51 patients with RRMS. The treatment was to be in the 8 mg/m2 administered intravenously once a month for a year. A were measured downward trend in disease activity by evaluating clinical outcomes and magnetic resonance imaging (MRI) and shown in this study.

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Cladribine (2-chlorodeoxyadenosine)

 
 Cladribine is an immunosuppressive agent that leads to the destruction of relatively selective cells (apoptosis) and because of its toxicity and cellular resistance to adenosine deaminase. Has been studied in patients who suffer from MS, and is used in the treatment of lymphoid malignancies and other autoimmune diseases.

Results after the first year of a double-blind crossover study, and placebo in 50 patients with MS-out, which was scheduled to last two years are favorable. Patients remained (measured in degrees and the total volume of neural lesion on MRI) stable or improved in patients treated with cladribine, but it became worse in patients who received placebo. These positive results have not, however, in recent randomized Phase III study in 159 patients out with MS receiving cladribine administered two different doses (and reiterates 0.7 or 2.1 mg / kg) or placebo. Topics that were monthly assessments for 12 months, and the serial number undergo evaluation of disability scores and classroom MRI. Although treatment with cladribine have a major impact in reducing lesions on MRI, there was no significant impact on the deficit. Side effects of this drug are myelosuppression and susceptibility to viral infection (including herpes zoster).

Methotrexate

Methotrexate is immune. The oral administration of a relatively low dose, effective and non-toxic in other autoimmune diseases such as rheumatoid arthritis and psoriasis. The first test showed in the treatment of MS some decline in the frequency of relapses, but no benefit in patients suffering from Multiple Sclerosis gradual.

In a recent study, 60 ambulatory patients with progressive MS, and moderate or severe disability in the methotrexate 7.5 mg per week or placebo for two years. In the group that received treatment, significantly reduced the damage in the composite endpoint (EDSS arm evaluation function), it was noted the maximum benefit of the study early.

However, this is not important treatment effect when analyzed according to the traditional endpoint and EDSS. The impact of the disease on MRI activity also marginal. This was well tolerated low-dose methotrexate and no patient treatment stalled because of adverse events. Can it be treated for long periods with methotrexate cause irritation of the mucous membranes, and gastrointestinal symptoms, liver, and pulmonary fibrosis, and myelosuppression.