Activity of the Disease,

Phase II studies (sample of 213 patients maximum) showed that relapse in MS, and monthly natalizumab injection given IV over a period of up to six months, and well-tolerated, and inhibits the activity of the disease, according to the (primary endpoint) MRI and reduces the frequency of relapses . Designed large Phase III trial to confirm the efficacy and safety of monthly management fourth natalizumab, either as a single therapy in combination with interferon beta.

Recent studies suggest that the beneficial effects of steroids and interferon beta in MS may be at least partly related to a reduction in the activity of certain MMPs and stimulating the production of tissue inhibitors MMPs. Also proved that MMP inhibitors effectively suppress EAE.

Can also manage future studies and nerve agents or molecules that renews axles, and the establishment of growth factors, and the proliferation and survival of oligodendrocytes (the cells that produce myelin) focus on stimulating the production of cell transplantation and myelin (for example, neural stem cells).

Home Toxic Effects

In a recently published the results of a multicenter European Phase II trial, which placebo-controlled, randomized, blind protocol.Found a significant positive impact on the frequency of relapses and the evolution of the deficit, and not accompanied by acute toxic effects. The information MRI beneficial effect on disease activity. Treatment was well tolerated. Although the results of this study led to the approval of mitoxantrone for the treatment of MS by the FDA in 2002, was not published the results in a scientific journal with peer review.

Home toxic effects of mitoxantrone is myelosuppression and cardiotoxicity dose.

Therefore, if the treatment with mitoxantrone, it is extremely important that patients who suffer from heart disease and an observer (depending on the treatment regimen used) ECG, blood and urine analysis to exclude the results on a monthly basis and an echocardiogram every six months.

Oral Treatment

Studies have shown, followed by magnetic resonance imaging (MRI), and the effect of steroids by it shows a decrease in lesion that leads to improved in the presence of gadolinium. However, this effect did not last long, however, and new lesions appear within a week after treatment. If often use corticosteroids in the treatment of advanced, little is known about their optimal dose system. In particular, there is no consensus on the relative effectiveness of various compounds (for example, ACTH intramuscularly, steroids IV or oral steroids), and optimal dose of each track management or the possible need for "oral treatment with low after management IV therapy of short duration continue. MPIV replace some doctors with oral corticosteroids in the treatment of recurrent disease because of the convenience of this type of management and reduce costs. We presented data indicate that the methods are equally effective in acute exacerbations, but it's not very convincing. It is interesting to note that in many of the studies of corticosteroids by mouth (concentrated all forces operating on a relatively small), and different dose regimens. And other anti-inflammatory drugs such as nonsteroidal anti-inflammatory non-steroidal (NSAIDs), and acetylsalicylic acid (aspirin), indomethacin, ibuprofen and naproxen did not prove effective in the treatment of MS acute

Bad effects of Tattooing

Allergies

The inks contain fairly limited amount of nickel, which some people extremely sensitive to cause allergy. It's rare but at a known allergy, it is well to prevent the tattoo artist who will test a test area to verify the allergy in ink. Allergy found to induce a tattoo impossible.

Bad effects of Tattooing

The pain varies by individual. However it is noted that the tattoo is usually painful. It is best to go in having slept well, ate well and being relaxed. A risk of fainting (vagal) can not be excluded if these parameters are not taken seriously. This raises the question of anesthetic cream. We must use it or not ... Some say that pain is part of the game ... The fact is that the pain is bearable. Being relaxed removes considerably. The disadvantage of this cream is that it changes the texture of the skin and the tattoo artist is more apt to work properly.

The Suggestion

The suggestion is equivalent to the insinuation. But what is the implication? Nothing but an attempt to convince someone of something. The suggestion may be verbal (the most common), but may well be tempted by exclusive looks, gestures or facial expressions.

There are examples of verbal suggestion, that is to say oral everywhere in everyday life. Most words have a suggestive power conscious or hidden. To this belong the various "preaching" instructive purposes, such as: "you must study well" or "thou shalt not you make friends for him." The compliment and condemnation are also a form of suggestion. Any compliment is a positive suggestion ("you're a gifted child," "You're a smart boy," "You're a wise little girl," "but what do you know how to cook") and any conviction a suggestion negative ("How to be stupid," "imbecile," "You'll never be a good for nothing", "you really have two left hands").

Those who are often treated to "be stupid" by willing or not begin to believe it. If "we will set the bar very low," he resigned himself to her as "stupid". The reverse is also true. Under the effect of positive suggestion ("well, you see you'll get there"), even the average person often goes far beyond a talented person but always treated as "stupid".

It is this principle that physicians use in practice to the healing of psychosomatic illnesses. The therapist begins to sleep lightly or hypnotize the patient (in many cases there is no major difference), then submits positive suggestions such as: "You feel better and better", "your heart issues steady beat, rhythm, "" your lungs, your kidneys are working very well "," you are again a person full of health and happiness. " The therapeutic effect is obtained through that suggestion.

No doubt you think that this process is somewhat silly (for me, all this seems infinitely primitive). However, the secret lies precisely in that, unlike its simplicity leads to the limit of absurdity, the suggestion runs an outstanding practice. This means that this method finds the possibility of obtaining a significant improvement in the condition of seven of ten patients, three or four completely get rid of their disease (before any of their psychosomatic problems).

No suggestion is an insinuation externally. People do not accept that someone "is trying to hammer them," but that also wish to accept. That is why the presence of the psychiatrist is often unnecessary. Try at first every day (and less often) to suggest that "today, my / my ... (substitute the appropriate word) is much better than yesterday." French pharmacist Coue, who was the first to employ this method, believed that many were sick just because they were being. Similarly, we can achieve cure in believing we are healthy.

Use of unconventional medicine by physicians

The Hippocratic oath updated indicates that the physician must respect "all persons [...] without any discrimination based on their status or their beliefs. Thus, even if not agree with unconventional medicine, a doctor may very well be used to meet the patient's beliefs. The use of unconventional medicine by a doctor, possibly within a hospital, is not a form of validation of the method. From a pragmatic point of view, as the method provides well-being and comfort to the patient, the doctor can use it even if it is satisfied that the effect is just placebo (conventional medicine also uses Frequently placebos). In the same vein, the presence of places of worship and chaplaincy in a hospital does not indicate that the nursing staff is a believer, but he respects the beliefs of patients and agrees to implement everything that is not harmful and brings comfort.

Nothing prevents a physician from practicing medicine unconventional. Their practice is not reserved for doctors. Many allied health professionals use them. They may be offered by persons who are not physicians or paramedics (nurses, physiotherapists, etc.;). Faces to the diversity of these unconventional practices with practitioners very heterogeneous attempts to regulations and controls are trying to implement.