Blood Brain Barrier

Agents to reduce the damage to the blood-brain barrier
 
 The blood-brain barrier (BBB) is to protect the spinal cord and brain by preventing the cells and molecules of some of the inputs. In the early stages of MS, this barrier more permeable, and can not prevent the immune cells from the blood. Its way to the brain and the spinal cord was observed that the management of IFN beta, to reduce patients and animals with EAE in BBB permeability, thus preventing the formation of new lesions.

Is evaluating a number of novel compounds soon in MS studies, including antibodies against adhesion molecules, adhesion molecules soluble recombinant that compete with the binding of activated lymphocytes T-, as well as other anti-competitive adhesion molecules, such as selectins. Natalizumab (AntegrenMD) and he was the head of monoclonal antibodies against leukocyte integrin alpha4beta1 studied recently.