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Cytokines and Activity

Factors that interfere with the production of cytokines and Activity
 
 Especially in this context, was supposed to TNF-alpha may play a very important role: and it is expressed in MS lesions, and there seems to be a relationship between the production of TNF alpha and clinical disease activity may be. Moreover, it was shown that they have a number of side effects, such as stimulating the production of several proinflammatory cytokines production and other toxic effects on oligodendrocytes, cells that have the CNS myelin. On the other hand, showed TNF-alpha anti-inflammatory properties. TNF inhibitors specific biological development (for example, monoclonal anti-TNF, soluble TNF receptor constructs) were evaluated in preliminary studies on MS. In a pilot study, and processes rapidly progressive MS humanized anti-TNF monoclonal antibody administered by intravenous infusion. This treatment led to a transient increase in the number of active lesions on MRI, accompanied by a temporary increase in the number of immune cells and the concentration in the cerebrospinal fluid, which are connected to activate the immune system and increase the activity treatment of diseases. In a study in North America, the second phase, 168 patients were treated for most RRMS with fusion protein TNF soluble receptor (LenerceptMD). The number of patients who have a much higher setbacks in the group that received treatment than it was in the second group, which emphasizes the need to better clarify the role of TNF alpha in September

Monoclonal Antibodies to Lymphocytes

Monoclonal antibodies to lymphocytes (or against some subtypes of lymphocytes)
Antibodies are specific antibodies very, which can be directed against specific molecules selectively (for example, produced by the cells or molecules against only certain subgroups of lymphocytes). This makes them a tool to induce immune selective.

This treatment produced a deep drain lymphocytes, and warned of the overall appearance of new lesions on MRI. Interestingly, it was observed with a longer clinical deterioration of the situation in a large proportion of patients, despite the absence of new lesions, complex also induced hyperthyroidism in about one-third of patients.

In a Phase II study, we have monoclonal anti-CD4 fictional administration to reduce the number of CD4 +, but this intervention had no effect on the disease as measured by magnetic resonance imaging.

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Blood Marrow Development

The Committee believes that all therapeutic strategies listed in this section ("Salaries in development") will be the subject of further research before they can be determine their usefulness in MS. Currently, there can be used recommended outside clinical trials planning correctly.

While there are undoubtedly necessary tools to develop effective strategies for highly treatment of MS, it would be wise to give a lot of optimism was premature and approach new therapeutic based on the results of studies on a small scale, without the completion of the third phase of studies on more staff. This shows the situation through the latter case of roquinimex (LinomideMD), immunoprecipitation, promising results completed in two phases Studies II, but unfortunately at the time of the third phase of tests had to be taken, involving more than 1,500 patients, because we realized that he had a severe toxicity and cardiovascular. In the case of a disease such as MS, which is characterized by progressive deterioration of the deficit for many years, and serious side effects, even if they are rare, lasting impact on the development of new therapeutic.

Immune Response,

According to some empirical data, it appears that this type of deviation can lead in fact to increase the production of immune antibodies and thus to the deterioration of the disease.

Develop vehicles that run on initiation of the immune response, especially at this stage where the antigen is served for T cells of antigen-presenting cells, the latter through specific receptors. According to studies of EAE (an animal model of MS) and this strategy seems promising.

Development of materials that reflect the blood-brain barrier to achieve stability in to restrict access to the central nervous system stimulant of immune cells. The relationship of this mechanism of magnetic resonance studies of IFN beta, which means that the effectiveness of the latter evidenced in part the impact of such on the blood-brain barrier, and demonstrated performance.

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Treatments in Development

  As mentioned above, refers to a growing body of evidence that the cause of MS is the result of a defect in the immune system, which lymphocytes, macrophages and cytokines play a pivotal role. Therefore, we have developed different strategies for therapeutic intervention on different parameters of the immune and inflammatory responses, or block. These strategies rely different orientations.

The development of drugs that stimulate the immune more selective to avoid potential side effects associated with generalized immune.

Development of materials. On cytokine production by promoting anti-inflammatory cytokines (IL-4, IL-5 and IL-10) at the expense of cytokine production pro-inflammatory (IL-2, IFN-gamma, alpha tumor necrosis factor) data indicate that IFN-beta clinical signs in reducing This much activity on MRI, along with a note that this will be the impact of a change in the balance between pro-inflammatory cytokines and anti-inflammatory cytokines is an important criterion for research in this area have lead.

Hematopoietic

Bone marrow or stem cells of Hematopoietic
 
 I will use bone marrow transplantation (BMT), widely in the treatment of various forms of cancer, and more recently, and the results of some studies that appeared it might be useful in the treatment of autoimmune diseases. They are strong immunosuppressive treatment with high-dose chemotherapy or total body radiation through (IV infusion) stem cells of hematopoietic bone marrow transplants. In the first months after transplantation BMT patients at high risk for complications, some fatal. This intervention was effective in EAE, and there is anecdotal evidence (well documented) effective September call A European study on bone marrow transplants and blood is currently developing guidelines specify criteria for selecting patients and transplant operations for future studies.

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